Prediction equations stratifying individuals with and without ACR measurements were derived internally and externally validated.<h4>Results</h4>Among individuals from Manitoba [53% women, mean (SD) age 51 (17), mean (SD) baseline eGFR 95 (14) mL/min/1.73 m<sup>2</sup>, median (interquartile range) ACR 0.7 mg/mmol (1-3)], incident CKD occurred in 11.4% during a median follow-up time of 4.5 (Q1 = 2.3, Q3 = 7.6) years of follow-up. This evidence concerns the gene ACR and chronic kidney disease.