MME and Down syndrome: We hypothesised that neutrophil subpopulations would significantly differ in abundance between people with MS and controls.<h4>Method</h4>Our pilot study applied flow cytometry to analyse phenotypes of neutrophils present in the peripheral blood of 10 people with recently active MS or clinically isolated syndrome (CIS) and 12 control participants.<h4>Results</h4>Using both unsupervised and supervised analyses of flow cytometry data, we identified that CD10<sup>low</sup> neutrophils were significantly enriched in the blood of people with CIS and MS compared with controls.