Further analysis showed that MMP8 knockdown was associated with reduced IL-17 signaling, while LCN2 knockdown led to inhibition of the NOD-like receptor pathway.<h4>Conclusion</h4>This study identified an eleven-gene signature that links IL-17 and NOD-like receptor signaling to megakaryocyte dysfunction and immune dysregulation in ET. The gene discussed is LCN2; the disease is essential thrombocythemia.