<h4>Objective</h4>This study aimed to analyze the epidemiological patterns of respiratory infectious diseases in Xiamen, Fujian Province, over the year following the relaxation of China's COVID-19 control measures.<h4>Methods</h4>We conducted a comprehensive statistical analysis of testing data for the six prevalent respiratory pathogens, utilizing throat swab antigen tests, PCR assays, and serological IgM testing. This evidence concerns the gene CD40LG and COVID-19.