Joint analysis of RNA-seq and ATAC-seq data demonstrated consistent downregulation of pivotal inflammatory pathways, such as NF-κB, Toll-like receptor, and TNF signaling.<h4>Conclusions</h4>With potent activity against viral replication and inflammation in cellular and animal models, MNS emerges as a promising candidate for the treatment of viral infections and hyperinflammatory conditions. Here, NFKB1 is linked to viral infectious disease.