Furthermore, clinical relevance was assessed using data from the National Health and Nutrition Examination Survey (NHANES, 2007-2010) to analyze correlations between hepatic steatosis and injury biomarkers.<h4>Results</h4>Viral exposure induced time-dependent upregulation and activation of STING, which driven the pathological accumulation of lipid droplets and subsequent ferroptotic cell death. This evidence concerns the gene STING1 and fatty liver disease.