A significant negative indirect effect was found (<i>β</i> = -0.065, 95% CI [-0.117, -0.027]), confirming ego depletion's suppressor role.<h4>Conclusion</h4>Ego depletion acts as a suppressor in the relationship between mindfulness and self-management in this sample of hospitalized IBD patients. The gene discussed is EGOT; the disease is inflammatory bowel disease.