Radiological evidence of pneumonia, in combination with elevated inflammatory markers (high-sensitivity C-reactive protein, procalcitonin, leukocytosis) and increased cardiac biomarkers (troponin, N-terminal pro-B-type natriuretic peptide), supported the diagnosis of SIMD. Targeted antibiotic therapy, cautious fluid management, and low-dose norepinephrine were administered. Here, CRP is linked to susceptibility to pneumonia measurement.