Transcriptomic reanalysis revealed dysregulation of FGL2 expression in IBS intestinal tissues, suggesting altered local immune regulation and a potential shift in the FGL2 isoform balance.<h4>Conclusion</h4>This study provides the first evidence that serum FGL2 levels are elevated in IBS-D and are associated with inflammation, symptom severity, and psychological distress. This evidence concerns the gene FGL2 and irritable bowel syndrome.