Transcriptomic reanalysis revealed dysregulation of FGL2 expression in IBS intestinal tissues, suggesting altered local immune regulation and a potential shift in the FGL2 isoform balance.<h4>Conclusion</h4>This study provides the first evidence that serum FGL2 levels are elevated in IBS-D and are associated with inflammation, symptom severity, and psychological distress. The gene discussed is FGL2; the disease is Abnormal emotional state.