TNFSF10 and cancer: <h4>Background</h4>Testicular germ cell tumors (TGCTs) are malignant neoplasms with a poor prognosis, and the absence of reliable biomarkers for patient stratification and diagnosis presents a significant challenge.<h4>Methods</h4>We employed an integrated analysis of Single-Cell RNA-Sequencing and TCGA data to evaluate TNFSF10 as a potential biomarker for prognosis and immunotherapy in TGCTs.<h4>Results</h4>Our findings revealed that aberrant TNFSF10 expression was significantly associated with patient survival outcomes.