Using <i>CALR</i> <sup><i>del52</i></sup> knockin mice, we observed that genetic ablation of <i>Cdk6</i> resulted in a reduction of spleen weight and platelet counts, while concurrently inducing interferon-associated transcriptional programs and upregulation of interferon-alpha receptor 1 (IFNAR1) on MPN cells. This evidence concerns the gene CDK6 and myeloproliferative disorder.