INS and Glucose intolerance: In contrast, C-HFD was characterized by increased circulating non-esterified fatty acids and beta-hydroxybutyrate levels compared to E-HFD mice, indicating enhanced fatty acid utilization.<h4>Conclusions</h4>E-HFD induced pronounced glucose intolerance and a blunted compensatory insulin response, while causing less tissue inflammation than C-HFD compared to standard chow.