METTL27 and liver dysplastic nodule: Furthermore, the 493 TF-6mRNA-183miRNA regulatory network of DN and 111 TF-4mRNA-33miRNA regulatory network of DR were constructed, among them, hsa-mir-101-3p was the common miRNA for ZNF223, NMNAT2 and TTC25, and EGR1 was the key TF which could regulate ATP4A, GAS6, METTL27, NMNAT2 and TTC25 at the same time.<h4>Conclusion</h4>This study revealed the potential molecular mechanisms of diagnostic genes in DN and DR, which could provide novel insights for the clinical diagnosis and treatment of DN and DR.