SYNGAP1 and epilepsy: <h4>Objective</h4>To summarize the clinical characteristics, treatment response, and prognosis of epilepsy associated with <i>SYNGAP1</i> gene variants.<h4>Methods</h4>Clinical and genetic data of six children diagnosed with SYNGAP1-related epilepsy at the Children's Hospital Affiliated to Zhengzhou University between November 2019 and February 2025 were retrospectively analyzed.<h4>Results</h4>Among the six patients (four males and two females), the median age at seizure onset was 2 years and 8 months.