<h4>Objectives</h4>Therefore, in the present study, the CB1 receptor (CB1R) expression in the hippocampal and cortical tissue of a clinically and neuropathologically characterized cohort of AD patients was analyzed.<h4>Methods</h4>Post-mortem brain tissue from patients with sporadic AD and non-demented control subjects was analyzed immunohistochemically, focusing on the hippocampus, medial frontal gyrus, and superior temporal gyrus. The gene discussed is CNR1; the disease is Alzheimer disease.