However, the characteristics of adaptive immune cells, including T-cell receptor (TCR) and B-cell receptor (BCR) repertoires, in MPE remain largely unclear.<h4>Methods</h4>In this study, we comprehensively characterized adaptive immune alterations in human lung adenocarcinoma-associated MPE and peripheral blood samples using single-cell RNA sequencing and single-cell V(D)J sequencing.<h4>Results</h4>No significant difference in complementary determining region 3 length distribution was observed among adaptive immune cell subsets between MPE and blood samples. The gene discussed is BCR; the disease is lung adenocarcinoma.