Its role is increasingly being noticed in cancers.<h4>Aims</h4>To conducted a pan-cancer analysis across multiple malignancies, as it allows for a comprehensive assessment of USP22 expression, regulation, and clinical impact.<h4>Methods</h4>The Human Protein Atlas, UALCAN, and Timer 2.0 were used to examine USP22 expression at the gene and protein levels in 33 TCGA cancer types. The gene discussed is USP22; the disease is cancer.