KIF11 and rheumatoid arthritis: Furthermore, KIF11 deficiency led to a profound decrease in the mRNA levels and protein secretion of cytokines in M1 macrophages.<h4>Conclusion</h4>Depletion of KIF11 markedly inhibited the proliferation, migration, and inflammatory cytokine secretion in MH7A and attenuated the maturation of M1 macrophages, as well as the production of inflammatory cytokines, suggesting its pivotal role in RA pathology.