Techniques included gene expression profiling, <i>N</i> <sup>6</sup>-methyladenosine methylation analysis, mitochondrial reactive oxygen species detection, lipophagy assays, lipid droplet staining, transcriptomic and proteomic analyses, ferroptosis sensitivity testing, and in vivo xenograft and metastasis models to investigate the role and underlying mechanisms of GPx3 in CRC. Here, GPX3 is linked to colorectal carcinoma.