In obstetric APS cohorts, pooled IgG AnxA5-Abs prevalence was 21.2% (95% CI 7.4-39.2) versus 4.0% (1.7-7.1) in controls; thrombotic APS showed 10.3% (5.7-15.8). This evidence concerns the gene ANXA5 and autoimmune polyendocrinopathy.