However, viral encephalitis induces CD4<sup>+</sup> and CD8<sup>+</sup> T cell infiltration and more <i>Lgals3/</i>MAC2-expressing macrophages surrounding dense-core Aβ plaques, which appear more compacted in JHMV-infected 5xFAD brains compared to uninfected 5xFAD controls. The gene discussed is CD4; the disease is viral encephalitis.