<b>Methods:</b> A cross-sectional study included 80 patients with T2DM and DKD in early (urine albumin-creatinine ratio (UACR) between 30 and 299 mg/g), group 1 (<i>n</i> = 29), and advanced stage (UACR ≥ 300 mg/g), group 2 (<i>n</i> = 51). The gene discussed is ALB; the disease is type 2 diabetes mellitus.