TLR4 and neoplasm: Using transcriptomic analysis, we now show that the top upregulated genes in <i>Pparg</i>-/-<sup>epi</sup> mouse skin, human AKs and cSCCs encode multiple damage-associated molecular patterns (DAMPs) that are TLR4 ligands, while the TLR4 agonist lipopolysaccharide (LPS) is also predicted to be the top common activated upstream regulator in both <i>Pparg</i>-/-<sup>epi</sup> mouse skin and in tumor datasets.