Overexpression of <i>DMTN</i> has been linked to the heme metabolism hallmark, disrupted iron distribution in COVID-19 patients with comorbid CAD, and subsequent stress erythropoiesis, oxidative stress, immunological dysfunction, and altered wound healing, while a lower expression of <i>PIWIL2</i> has been observed in the cytoplasmic translation and regulation of mRNA metabolism. Here, PIWIL2 is linked to COVID-19.