Compared with untreated endometriosis, terazosin significantly reduced SF-1, PGE2, IL-6, IL-8, TNF-α, VEGF and HIF-1α across compartments (all <i>p</i> < 0.001), comparable to leuprolide (<i>p</i> = 1.000). Here, CXCL8 is linked to endometriosis.