Whole exome sequencing was performed, focusing on non-causative variants (n = 64) in the key AD (<i>APP</i>, <i>PSEN1</i>, <i>PSEN2</i>) and FTD genes (<i>MAPT</i>, <i>GRN</i>, <i>C9orf72</i>). This evidence concerns the gene APP and Alzheimer disease.