This research examines the combined neuroprotective and nephroprotective properties of three medicinal plants, <i>Mucuna pruriens</i> (Muc), <i>Moringa oleifera</i> (Mor), and <i>Silybum marianum</i> (SM), in a murine model of PD, AKI, and their comorbid state (PD-AKI), highlighting the role of the PI3K/AKT/mTOR and Nrf2/NF-κB signaling pathways. Here, NFKB1 is linked to Parkinson disease.