ADIPOQ and polycystic ovary syndrome: The pooled analysis demonstrated significantly lower adiponectin levels in adolescents with PCOS compared to controls (mean difference [MD]: -3.19 μg/mL; 95% CI: -4.90 to -1.49; <i>p</i> = 0.0010), with substantial heterogeneity (I<sup>2</sup> > 90%).