<b>Methods</b>: This study included cardiac arrest survivors with sufficient data to calculate the Pittsburgh Cardiac Arrest Category (PCAC) and revised post-cardiac arrest syndrome for therapeutic hypothermia (rCAST) scores who underwent brain magnetic resonance imaging and cerebrospinal fluid neuron-specific enolase (CSF-NSE) measurement within 6 h after return of spontaneous circulation. Here, ENO2 is linked to cardiac arrest.