Therefore, finding methods to inhibit pancreatic cancer metastasis has important clinical value.<h4>Methods</h4><i>N</i>-dihydrogalactochitosan (GC) is an immunostimulant that can enhance the anti-tumor immune response to inhibit metastasis in combination with photothermal therapy.<h4>Results</h4>Here, we found that GC can inhibit the migration of pancreatic cancer cells through interactions with caveolin-1 (Cav-1). Here, CAV1 is linked to familial pancreatic carcinoma.