CD8A and neoplasm: We investigated whether spatial proximity between PD-L1(+) tumor-associated macrophages (TAMs) and CD8(+) T cells represents an immune niche associated with Atezo+Bev responsiveness.<h4>Methods</h4>Multiplex immunohistochemistry was performed on biopsies from patients treated with Atezo+Bev (<i>n</i> = 23) or lenvatinib (<i>n</i> = 20).