Mechanistically, NSUN4 bound to and stabilized C-MYC mRNA via m<sup>5</sup>C methylation, activating the PI3K/Akt signaling pathway and promoting ferroptosis resistance.<h4>Conclusions</h4>NSUN4 promotes cervical cancer progression by stabilizing C-MYC mRNA through m<sup>5</sup>C modification, leading to PI3K/Akt activation and suppression of ferroptosis. The gene discussed is MYC; the disease is cervical cancer.