<b>Results</b>: Screens in both cell lines converged on DDR pathways, particularly nucleotide excision repair (NER) and the Fanconi anemia/interstrand crosslink repair network; shared sensitizers included <i>ERCC4</i> (<i>XPF</i>), <i>FANCE</i> and <i>SLX4</i>. The gene discussed is SLX4; the disease is Fanconi anemia.