RNA-seq and ChIP analyses further identified three novel candidate target genes (<i>SLC6A14</i>, <i>GABRG1</i>, and <i>AKR1B10</i>), suggesting that SALL1 may exert a tumor-suppressive effect, at least in part, through negative regulation of these genes.<h4>Conclusions</h4>These findings establish SALL1 as a possible tumor suppressor and provide new insights into the biological significance of SALL1 downregulation in HCC. Here, AKR1B10 is linked to hepatocellular carcinoma.