This study aimed to explore whether ER-α36 promotes gastric cancer progression by regulating serum and glucocorticoid-regulated kinase 1 (SGK1)-mediated Erk1/2 activation.<h4>Methods</h4>We collected 53 human gastric adenocarcinoma specimens and detected ER-α36 expression by immunohistochemistry. The gene discussed is MAPK3; the disease is gastric adenocarcinoma.