Immune infiltration research revealed that patients with high CRIF1 expression had higher CD8<sup>+</sup> T cell expression but reduced macrophage M2 expression.<h4>Conclusion</h4>Upregulation of CRIF1 in breast cancer cells enhances malignant behavior, which may be mediated by PI3K/AKT/mTOR signaling and is linked to cellular autophagy. The gene discussed is GADD45GIP1; the disease is breast cancer.