JAK2 and essential thrombocythemia: Two recurrent CRAO episodes occurred over the following 2 years, with platelet counts persistently elevated.<h4>Diagnoses</h4>Bone marrow biopsy revealed megakaryocytic hyperplasia, and genetic testing confirmed JAK2 mutation, establishing the diagnosis of ET.<h4>Interventions</h4>The patient was treated with hydroxyurea and aspirin.<h4>Outcomes</h4>Following treatment, the patient achieved normalization of platelet levels with no further episodes of amaurosis.