Headache severity was significantly more in APS patients (p = 0.04) Factors affecting headache severity were APS disease duration, BMI, triple aPL positivity (p = 0.03, 0.00, 0.02 respectively).<h4>Conclusion</h4>Primary and secondary types of headaches are frequently reported in Patients with APS, primary headache being more common; migraine in particular. Here, FASLG is linked to autoimmune polyendocrinopathy.