SLC5A2 and hydrops fetalis: Drug prediction suggested multiple candidates, including β-blockers, RAAS inhibitors, anti-fibrotic agents, vericiguat, metformin, and SGLT2 inhibitors.This integrative analysis of HF transcriptomics reveals potential immune remodeling, hub genes, and repurposable drugs relevant to LBBP response heterogeneity, providing hypothesis-generating insights and potential therapeutic strategies for validation in LBBP-specific cohort.