Dopaminergic markers like TH, BDNF, NR4A2 (Nurr1), PINK1, and SYNGR3 were notably upregulated in differentiated cells, whereas A53T mutant α-synuclein overexpression was associated with significant downregulation of 22 genes associated with PD, including TH, NR4A2, BDNF, and PINK1, suggesting alterations in neuroprotective signaling pathways. The gene discussed is PINK1; the disease is Parkinson disease.