Higher PCBP1 expression was associated with poorer overall survival (OS) and recurrence-free survival (RFS) in CRC, and PCBP1 showed a positive association with PD-L1 by immunohistochemistry in an exploratory analysis.<h4>Conclusion</h4>These findings provide supportive evidence that gut microbiota changes and host gene signals are linked to the PSC-CRC association. This evidence concerns the gene PCBP1 and colorectal carcinoma.