Integrated chemical, biological, and computational analyses identified trigonelline as a major active constituent contributing to the anti-psoriatic effects of SN.<h4>Discussion</h4>SN ameliorates psoriasis-like dermatitis primarily through suppression of NLRP3 inflammasome signaling, with trigonelline identified as a key contributory active component. This evidence concerns the gene NLRP3 and skin disorder.