Recent findings revealed increased plasma PIGR levels in subjects with subclinical atherosclerosis, although its function remains uncertain.<h4>Purpose</h4>To assess the role of PIGR in atherosclerosis.<h4>Methods</h4>We analyzed PIGR levels in human atherosclerotic plaques compared to healthy aortic samples, as well as in the serum of subjects with peripheral arterial disease (PAD) and controls. Here, PIGR is linked to peripheral arterial disease.