However, the precise mechanisms in CRC progression, particularly the metabolic reprogramming processes, remain unclear.<h4>Methods</h4>This study integrated transcriptomic, metabolomic, genome-wide ChIP-seq and summary-data-based Mendelian randomization (SMR) analyses in CRC cells and patient cohorts to study the WSTF regulatory network. Here, BAZ1B is linked to colorectal carcinoma.