The in vivo effects were further evaluated in influenza A virus (IAV)-infected mice using a FeCl<sub>3</sub>-induced carotid artery thrombosis model, where thrombus formation and blood flow were monitored.<h4>Results</h4>The saponin fraction markedly inhibited platelet aggregation, enhanced cGMP production, and increased phosphorylation of IP<sub>3</sub>R and VASP Ser<sup>239</sup>. The gene discussed is VASP; the disease is carotid artery thrombosis.