<h4>Background</h4>We investigated the impact of <i>Helicobacter pylori</i> eradication on the expression of Ki67, p53, and cyclin D1 in patients diagnosed with chronic gastritis and intestinal metaplasia, utilizing the immunohistochemistry (IHC) method.<h4>Methods</h4>The immunoexpression of Ki67, p53, and cyclin D1 in the gastric mucosa was analyzed in 26 patients with chronic gastritis, intestinal metaplasia, and confirmed <i>H. This evidence concerns the gene CCND1 and chronic gastritis.