&lt;i&gt;Rhodomyrtus tomentosa&lt;/i&gt; fruit ameliorates LPS induced depression-like behaviors in mice by attenuating hippocampal neuroinflammation via inhibiting the TLR4/MyD88/MAPK/NF-κB/NLRP3 signaling pathway. The gene discussed is NLRP3; the disease is major depressive disorder.