Analysis of adiponectin oligomers evidenced a significant down regulation of HMW and MMW isoforms in sarcopenic vs. pre-sarcopenic and non-sarcopenic patients.<h4>Discussion</h4>Our findings support the pivotal role of metabolic and nutritional disorders in muscle loss in CD patients and indicate adiponectin and phase angle as complementary biomarkers of sarcopenia. This evidence concerns the gene ADIPOQ and sarcopenia.