Cognitive assessment was performed using the Minimal Assessment of Cognitive Function in Multiple Sclerosis (MACFIMS) by a trained individual.<h4>Results</h4>Based on CI criteria, 24 patients (48.98%) were classified as cognitively impaired, of whom 20 (83.33%) were AQP4-IgG seropositive. Here, AQP4 is linked to multiple sclerosis.