Multivariate linear regression analysis was used to determine the relationship between VEGFR2 levels and the severity of CAD.<h4>Results</h4>Patients with OSA and CAD demonstrated remarkably higher circulating VEGFR2 levels compared with those patients with OSA alone (median interquartile range (IQR): CAD 10.9 (8.26-14.6) vs. non-CAD 8.25 (5.87-10.3) ng/mL; *<i>p</i> < 0.05). This evidence concerns the gene KDR and obstructive sleep apnea syndrome.